There doesn't necessarily have to be any offence, and this doesn't necessarily have to be about pronouns. Suppose A/B testing on your site shows that female use

There doesn't necessarily have to be any offence, and this doesn't necessarily have to be about pronouns. Suppose A/B testing on your site shows that female users are more likely to buy your product with a given display alternative over another, while males prefer the opposite. If you guess wrong, you would not be offending users by showing their least likely preferred alternative; you would just be reducing your chances of making a sale.