3 ms·

From the paper [0]: "Modified human fasting mimicking diet. A single cycle of the modified fasting mimicking diet consist of Day 1 – pre-fasting followed by D

by biot 10y ago

From the paper [0]: "Modified human fasting mimicking diet. A single cycle of the modified fasting mimicking diet consist of Day 1 – pre-fasting followed by Day 2-8 – very low calorie diet. Day 1-prefasting consists of an 800 kcal (about 40% of normal caloric intake similar to mouse Day1 FMD) monodiet (fruit, rice, or potatoes) by preference of individuals. On the following day patients were recommended to use an oral laxative, Natrium Sulfuricum (20-40 g). FMD consisted of 100 ml vegetable broth or vegetable juice with 1 tablespoon of linseed oil 3 times daily, plus additional calorie-free liquids. The daily calorie intake was predefined with 200 – 350 kcal (10-18% of normal caloric intake similar to mouse Day 2-3 FMD). Patients were advised to drink 2-3 L of unsweetened fluids each day (water, and herbal teas) and to use an enema if tolerated. After the 7-day fasting period solid foods were stepwise reintroduced for three days, starting with a steamed apple at day 8. After the fasting and refeeding period a normocaloric, plant-based Mediterranean diet was maintained until study end." [0] http://www.cell.com/cell-reports/pdfExtended/S2211-1247(16)30576-9 http://www.cell.com/cell-reports/pdfExtended/S2211-1247(16)3...

joveian 10y ago
If this is a real effect, I wonder how many calories a persona can eat and still get the fasting effect. I have a non-24 hour circadian rhythm (although some thing still seem synchronized to light), which causes all sorts of negative effects, and I have found that eating < about 1500 kcal in a day reliably causes a significant improvement in my functioning two days later. Normally eating between 1500 and 2000 kcal most days does not cause this improvement. I am curious if what I am seeing is the same effects as would be caused by this much lowerer calorie diet or if there are tiers of fasting with different effects. Also interesting is that I have had some severe digestive issues for years; antibiotics helped for a month or two and eating about 3000 kcal over five days has been just as helpful for a couple of weeks now and seems likely to be at least as effective as the antibiotics. However, one or two days of calorie restriction does not have that effect on me. If this fasting result holds for MS, the effect of fasting on gut bacteria could potentially be part of how it works.
aruggirello 10y ago
Oddly enough, Natrum Sulphuricum seems to be a homeopathic remedy, not a common laxative - can anybody shed some light on this?
ludamad 10y ago
Why the enema?

by biot 10y ago

joveian 10y ago

If this is a real effect, I wonder how many calories a persona can eat and still get the fasting effect. I have a non-24 hour circadian rhythm (although some thing still seem synchronized to light), which causes all sorts of negative effects, and I have found that eating < about 1500 kcal in a day reliably causes a significant improvement in my functioning two days later. Normally eating between 1500 and 2000 kcal most days does not cause this improvement. I am curious if what I am seeing is the same effects as would be caused by this much lowerer calorie diet or if there are tiers of fasting with different effects. Also interesting is that I have had some severe digestive issues for years; antibiotics helped for a month or two and eating about 3000 kcal over five days has been just as helpful for a couple of weeks now and seems likely to be at least as effective as the antibiotics. However, one or two days of calorie restriction does not have that effect on me. If this fasting result holds for MS, the effect of fasting on gut bacteria could potentially be part of how it works.

aruggirello 10y ago

Oddly enough, Natrum Sulphuricum seems to be a homeopathic remedy, not a common laxative - can anybody shed some light on this?

ludamad 10y ago

Why the enema?