3 ms·
Cancer is complicated, but it emphatically is a _genetic_ disease, with inherited _genetic_ risk factors. Environmental influences are typically mediated by th
by alevskaya 10y ago
Cancer is complicated, but it emphatically is a _genetic_ disease, with inherited _genetic_ risk factors. Environmental influences are typically mediated by their ability to cause or promote mutation via cell stress (e.g. by promoting local inflammation) and cell proliferation, which in turn increases mutation load. There are subtler influences that could weaken the natural immunosurveillance of neopeptides by T-cells, but the importance of such surveillance in prevention is debated and perhaps more relevant in later-stage cancers. We may not fully understand such a complicated disease, but with modern sequencing we have a pretty good lens on the phenomenology of emergence of cancer, and that "subjective plausibility" is a working gut-bayesian framework that doesn't put a strong prior on ambient microwaves as a likely causative factor. Also, the field of RF- and microwave- induced cancer has been a long-running cottage industry producing bad science for many years now: i.e. studies with poor statistical power and poor replicability… so there’s a reason skepticism prevails on this point among biologists. It’s not just dogmatism: if anyone can get a replicable animal model we could dive into it to find new mechanisms… but these results always seem to sit at the edge of detection.
- dragonwriter 10y ago> Environmental influences are typically mediated by their ability to cause or promote mutation That may be typical, in that there are definitely lots of environmental influences that work that way, but its been established for at least on the order of a couple of decades that there are also influences that impact the emergence and development of cancer when potentially cancer-causing mutations exist, and that genetics while important to cancer, aren't the whole story and mechanism. Attributes of the extracellular matrix, which can definitely be affected by physical and chemical effects that are not mutagenic, are one of the established influences.