> A lot of really wild promises about 20-30 years too early, then when the real stuff starts to happen everyone is long since tired of all the hype.... but that

> A lot of really wild promises about 20-30 years too early, then when the real stuff starts to happen everyone is long since tired of all the hype.... but that's when the real stuff starts to happen. Here's a paper showing how to make fluorescent reporters from 1995: http://www.ncbi.nlm.nih.gov/pubmed/8777060 http://www.ncbi.nlm.nih.gov/pubmed/8777060 But I agree, the real stuff is a long-term accumulation of studies building on each other. The reporters were (and still are) interesting/useful for people in molecular biology... but their application is only now becoming interesting/useful for others.