4 ms·
Redesigning the human metabolism to eliminate aging is a project of such vast complexity as to be far, far beyond our present horizons. Consider that it took a
by reasonattlm 10y ago
Redesigning the human metabolism to eliminate aging is a project of such vast complexity as to be far, far beyond our present horizons. Consider that it took a few billion dollars and the last fifteen years to gather a little more knowledge of sirtuins, one very tiny slice of mammalian biochemistry related to the calorie restriction response, the most reliable and well-studied way to slightly slow down aging. The research and development community can't even provide a timeline for mimicking even a small fraction of this natural state reliably and safely. Making a whole new human biochemistry that works more like lobsters or hydra? Not until very late this century, I'd imagine, will this be something plausible as a long-term vision.
Meanwhile there is in fact an easy path to eliminating aging. Aging is damage accumulation at root. The easy path is to periodically repair that damage - the damage is already identified, after all. Sufficiently good maintenance is the road to eliminating aging; let it happen but control it. Maintain the biochemistry we have and that we know works.
http://www.sens.org/research/introduction-to-sens-research http://www.sens.org/research/introduction-to-sens-research
This has a large weight of evidence behind it, and approaches are already being demonstrated in the case of senescent cell clearance, removal of transthyretin and beta amyloids, and averting the consequences of mitochondrial DNA damage. Others will follow as results become more compelling.