This list includes a few nobel prize winners: https://en.wikipedia.org/wiki/Self-experimentation_in_medicine https://en.wikipedia.org/wiki/Self-experimentation

This list includes a few nobel prize winners: https://en.wikipedia.org/wiki/Self-experimentation_in_medicine https://en.wikipedia.org/wiki/Self-experimentation_in_medici... The fact that these folks driven to test on them selves is a fair indication of how bounded the box can be. https://en.wikipedia.org/wiki/Werner_Forssmann https://en.wikipedia.org/wiki/Werner_Forssmann and https://en.wikipedia.org/wiki/Barry_Marshall https://en.wikipedia.org/wiki/Barry_Marshall Are two great examples of folks going way out of the box to prove a point, and seeing reward for it.