Since that interview, a lot of interesting developments have happened on the web, e.g. proliferation of VoIP, mobile dev, microblogging and real-time search. I

Since that interview, a lot of interesting developments have happened on the web, e.g. proliferation of VoIP, mobile dev, microblogging and real-time search. It does seem like the fields you mention are ripe for innovation, though. I wonder if CS will be playing a significant auxiliary role.