Not the platform you're asking about, but in Binary Ninja, you right-click on the conditional jump and choose "Always Branch", "Never Branch", or "Invert Branch

Not the platform you're asking about, but in Binary Ninja, you right-click on the conditional jump and choose "Always Branch", "Never Branch", or "Invert Branch". Binary Ninja also supports inline editing of assembly and a custom compiler for dropping simple C replacements directly on top of existing functionality.