NAT64/DNS64 is completely invisible to the endpoint - there is zero differentiation between how a client talks to a native IPv6 resource and an IPv4 resource.

NAT64/DNS64 is completely invisible to the endpoint - there is zero differentiation between how a client talks to a native IPv6 resource and an IPv4 resource. All of the translation is handled by the network/DNS, so if your app works with your device configured with only a v6 IP address while supported by a NAT64/DNS64 network, you're good to go.