Major differences are: - In uBlock Origin you can allow/block on a per-site basis with one click -- you do not need to allow one specific domain everywhere. (I

Major differences are: - In uBlock Origin you can allow/block on a per-site basis with one click -- you do not need to allow one specific domain everywhere. (I am aware NoScript's ABE can get the same result, but that requires more than a single click.) - You can block on a 1st-/3rd-party basis. I consider the default blocking of 3rd-party scripts while allowing 1st-party scripts to be the optimal solution for cutting bloat with less web page breakage. Now keeping 1st point in mind, this means one could allow all 3rd-party scripts on one specific site, while keeping them blocked everywhere else by default. - Whatever is not taken care by dynamic filtering will fall onto static filtering, i.e. even if one end up allowing 3rd-party scripts, the static filters will pick up the task of blocking nuisance scripts.