4 ms·

You should read the last book of Maria Blasco [0], arguably the best (or at least in the top 3 researchers in the telomeres/telomerase field), and main author o

by joeyspn 11y ago

You should read the last book of Maria Blasco [0], arguably the best (or at least in the top 3 researchers in the telomeres/telomerase field), and main author of the science that has inspired BioViva's work. The book is titled: "Morir joven, a los 140" (english: "Dying young, at 140") [1] I'm going to take the time to paste here a brief excerpt translated into english: "Is aging mandatory? Until recently, serious science did not deal with that question. After all, having ailments is normal over the years. However, what is normal today, may not be tomorrow. Mankind has grown accumulating victories against natural and normal phenomena, like high infant mortality. Fact is that more and more scientists say that not only aging can be combated, but we also must: prolonging youth could be the way to prevent cancer, Alzheimer's, and age diseases as a whole." > Aging isn't something you can simply disrupt with a silicon valley mindset. Usually I listen to people like Maria, who's been at it for 30+ years (not to random people in the internets with marketing and sales background). It's inspiring reading works of scientists and people so open minded, which is IMHO the essence of Silicon Valley. > I've met organic chemists who have spent upwards of 30 years developing drugs and haven't put a single drug on the market. Maybe because it costs a minimum of 1 billion and 10+ years of approval (plus the consent of the gatekeepers)? [0] https://www.google.es/search?num=100&q=maria+blasco+telomerase https://www.google.es/search?num=100&q=maria+blasco+telomera... [1] https://www.amazon.es/Morir-Joven-Los-Maria-Blasco/dp/8449332060 https://www.amazon.es/Morir-Joven-Los-Maria-Blasco/dp/844933...

kumarski 11y ago
I should read the book. That's fine, listen to Maria, but don't criticize me for asking valid questions, albeit somewhat bias. It does not cost a minimum of 1 billion and 10 years of approval. The cost deconstruction of pharma trials is complicated. As well, there's more to the dark/light side of pharma industry than generics companies. If you'd like to talk shop about it, email me. I can share deep insights after talking to over 100+ people in the pharma industry, visiting labs, and much more.
- joeyspn 11y ago
  > [...] don't criticize me for asking valid questions Your questions are misplaced and have been probably answered before [0]. I'm just astonished by the fact that you are dismissing decades of research by some of the best and most awarded oncologists in Europe. You can't just say that "Manipulating telomeres to investigate aging sounds like a joke", when evidence (98% of the research in the field) points to the contrary. Maybe you don't not agree with Bioviva's highly dangerous and non-standard methods for circumventing slow and expensive trials (I do not either), but that's another whole issue. > I can share deep insights after talking to over 100+ people in the pharma industry, visiting labs, and much more. Thanks but I have a well formed opinion about what happens inside the industry. I've also worked in the space for some years. > It does not cost a minimum of 1 billion [...] Current average seems to be $2.6B. Could you share your sources? http://www.forbes.com/sites/matthewherper/2013/08/11/how-the-staggering-cost-of-inventing-new-drugs-is-shaping-the-future-of-medicine/#5f9cdc76bfcb http://www.forbes.com/sites/matthewherper/2013/08/11/how-the... http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/#44097de04477 http://www.forbes.com/sites/matthewherper/2012/02/10/the-tru... http://www.nytimes.com/2014/11/19/upshot/calculating-the-real-costs-of-developing-a-new-drug.html?_r=0 http://www.nytimes.com/2014/11/19/upshot/calculating-the-rea... https://www.bostonglobe.com/business/2014/11/18/cost-bringing-prescription-drug-market-tops-billion-tufts-research-center-estimates/6mPph8maRxzcvftWjr7HUN/story.html https://www.bostonglobe.com/business/2014/11/18/cost-bringin... http://www.patentdocs.org/2015/03/guest-post-26-billion-per-drug-is-your-patent-portfolio-strong-enough-to-protect-your-investment.html http://www.patentdocs.org/2015/03/guest-post-26-billion-per-... [0] https://www.reddit.com/r/Futurology/comments/3ocsbi/ama_my_name_is_liz_parrish_ceo_of_bioviva_the/ https://www.reddit.com/r/Futurology/comments/3ocsbi/ama_my_n...
  - kumarski 11y ago
    Was I dismissive of Maria's research? It's fine to form an opinion, I was offering a deeper connection because I'm always open to learning from others. My objections to crowdsourcing and aggregating information about drug development costs: http://blogs.sciencemag.org/pipeline/archives/2015/10/14/jack-scannell-talks-loads-of-sense-on-drug-pricing http://blogs.sciencemag.org/pipeline/archives/2015/10/14/jac... I don't fundamentally agree with any of the claims Bioviva is making around the data they've collected to consumers at large.

by joeyspn 11y ago

kumarski 11y ago

I should read the book. That's fine, listen to Maria, but don't criticize me for asking valid questions, albeit somewhat bias. It does not cost a minimum of 1 billion and 10 years of approval. The cost deconstruction of pharma trials is complicated. As well, there's more to the dark/light side of pharma industry than generics companies. If you'd like to talk shop about it, email me. I can share deep insights after talking to over 100+ people in the pharma industry, visiting labs, and much more.

joeyspn 11y ago
> [...] don't criticize me for asking valid questions Your questions are misplaced and have been probably answered before [0]. I'm just astonished by the fact that you are dismissing decades of research by some of the best and most awarded oncologists in Europe. You can't just say that "Manipulating telomeres to investigate aging sounds like a joke", when evidence (98% of the research in the field) points to the contrary. Maybe you don't not agree with Bioviva's highly dangerous and non-standard methods for circumventing slow and expensive trials (I do not either), but that's another whole issue. > I can share deep insights after talking to over 100+ people in the pharma industry, visiting labs, and much more. Thanks but I have a well formed opinion about what happens inside the industry. I've also worked in the space for some years. > It does not cost a minimum of 1 billion [...] Current average seems to be $2.6B. Could you share your sources? http://www.forbes.com/sites/matthewherper/2013/08/11/how-the-staggering-cost-of-inventing-new-drugs-is-shaping-the-future-of-medicine/#5f9cdc76bfcb http://www.forbes.com/sites/matthewherper/2013/08/11/how-the... http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/#44097de04477 http://www.forbes.com/sites/matthewherper/2012/02/10/the-tru... http://www.nytimes.com/2014/11/19/upshot/calculating-the-real-costs-of-developing-a-new-drug.html?_r=0 http://www.nytimes.com/2014/11/19/upshot/calculating-the-rea... https://www.bostonglobe.com/business/2014/11/18/cost-bringing-prescription-drug-market-tops-billion-tufts-research-center-estimates/6mPph8maRxzcvftWjr7HUN/story.html https://www.bostonglobe.com/business/2014/11/18/cost-bringin... http://www.patentdocs.org/2015/03/guest-post-26-billion-per-drug-is-your-patent-portfolio-strong-enough-to-protect-your-investment.html http://www.patentdocs.org/2015/03/guest-post-26-billion-per-... [0] https://www.reddit.com/r/Futurology/comments/3ocsbi/ama_my_name_is_liz_parrish_ceo_of_bioviva_the/ https://www.reddit.com/r/Futurology/comments/3ocsbi/ama_my_n...
- kumarski 11y ago
  Was I dismissive of Maria's research? It's fine to form an opinion, I was offering a deeper connection because I'm always open to learning from others. My objections to crowdsourcing and aggregating information about drug development costs: http://blogs.sciencemag.org/pipeline/archives/2015/10/14/jack-scannell-talks-loads-of-sense-on-drug-pricing http://blogs.sciencemag.org/pipeline/archives/2015/10/14/jac... I don't fundamentally agree with any of the claims Bioviva is making around the data they've collected to consumers at large.