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Genetic secrets of the healthy elderly unveiled
- tosseraccount 11y agoCited Journal "Cell" publication here : http://www.cell.com/cell/fulltext/S0092-8674%2816%2930278-1?rss=yes http://www.cell.com/cell/fulltext/S0092-8674%2816%2930278-1?... Whole Genome Sequencing of a Healthy Aging Cohort. Key quotes: "The top region is a large linkage block at MHC locus 6p22.1 ... This region contains a handful of SNPs that have been replicated and confidently associated with cognitive traits, including rs1056667, associated with cognitive performance" "The second sub-significant region included lead SNP rs156033 (p value = 1.7 × 10−6), in the 5q31.1 region, which contains SLC22A4 and multiple variants ... strongly associated with carnitine and carnitine-related metabolite levels" "third sub-significant region included lead SNP rs10209741 (p value = 7.0 × 10−6) in the 2q36.1 region containing KCNE4 and nearby (11.4 kb) rs895767, which was previously associated with cognitive decline" notes: MHC = major histocompatibility complex, a set of cell surface proteins essential for acquired immune system to recognize foreign molecules in vertebrates. carnitine = eukaryote specific nutrient involved in lipid metabolism KCNE4 = a voltage-gated potassium (Kv) channel SLC22A4 = integral plasma membrane protein , ergothioneine transporter. Foods found to contain ergothioneine include liver, kidney, black beans, kidney bean and oat bran [ wikipedia ].