4 ms·
Cool. So they basically took away Cas9's ability to cut, but retained its ability to target specific loci on the genome. Then attached an enzyme that converts t
by daemonk 10y ago
Cool. So they basically took away Cas9's ability to cut, but retained its ability to target specific loci on the genome. Then attached an enzyme that converts the base.
Changing the other combinations of bases might be tricky. Not sure if there are existing enzymes that will perform those functions biochecmically, as C -> U conversion is relatively simpler compared to other conversions.