You should go read about MRSA, which shouldn't exist according to your logic. You also are misunderstanding how independent assortment of alleles work. Because

You should go read about MRSA, which shouldn't exist according to your logic. You also are misunderstanding how independent assortment of alleles work. Because plasmodium is a eukaryotic species which reproduces sexually, on-target resistance mutations to any number of mechanisms can arise independently in a bunch of different organisms and accumulate through selection + allele segregation. It's also very easy to produce these sorts of mutations, since it is trivial to change an amino acid to disrupt antibody binding/recognition without altering the function of the protein. >Which can be targeted to eliminate the mosquitos themselves. This is incorrect; the whole point of a gene drive is that it causes increased propagation of a trait in the mosquito population. What you're describing is a very different strategy, since a trait that kills the mosquito obviously cannot propagate. It can also be achieved much more simply by using sterile males to outcompete fertile males and reduce the population ('sterile insect' technique); however, this technique only works on small populations and almost certainly wouldn't work in Anopheles or some such.