3 ms·
You can break it down further into two separate surprises: 1) The normal form (PrPc) is mostly helical, while the diseased form (PrPsc) is mostly beta-sheet. 2
by gilleain 11y ago
You can break it down further into two separate surprises:
1) The normal form (PrPc) is mostly helical, while the diseased form (PrPsc) is mostly beta-sheet.
2) PrPsc catalyses the switch from helix to sheet.
I find the first to be more surprising. After all, chaperones (https://en.wikipedia.org/wiki/Chaperone_(protein) https://en.wikipedia.org/wiki/Chaperone_(protein)) exist to catalyse folding of proteins - although that is from partly folded to fully folded.