4 ms·
Just to clarify, all over the counter painkillers are NSAIDs, non steroidal anti inflammatory drugs. And like OC said, they all inhibit COX1 and COX2. Selective
by goldenkey 11y ago
Just to clarify, all over the counter painkillers are NSAIDs, non steroidal anti inflammatory drugs. And like OC said, they all inhibit COX1 and COX2. Selective COX1 inhibitors have been created as prescription drugs to avoid effects of stomach ulcers and liver damage but were pulled off the market due to studies showing increased risk of heart attacks. Ie. Celebrex
https://en.m.wikipedia.org/wiki/Celecoxib https://en.m.wikipedia.org/wiki/Celecoxib
https://en.m.wikipedia.org/wiki/NSAID https://en.m.wikipedia.org/wiki/NSAID
- DanBC 11y agohttps://en.m.wikipedia.org/wiki/NSAID https://en.m.wikipedia.org/wiki/NSAID > Paracetamol (acetaminophen) is generally not considered an NSAID because it has only little anti-inflammatory activity. It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body.[3]
- goldenkey 11y agoPersonally I take Naproxen Sodium (Aleve.) It has a long half life and high anti-inflammatory activity. One thing to note is that NSAIDs are best taken in high doses sparingly rather than a temperate dose daily. Inflammation is best defeated by impulse of NSAIDs. I suffer from chronic pain due to herniated discs. When I notice it is due to inflammation I take 2 Aleve extra strength gel caps. And the inflammation subsides for at least a week or two. I know this isnt totally related and slightly anecdotal but as hackers I figure that you guys would like to know from a fellow hacker that did the research.
- maxerickson 11y agoThe studies that led to those drugs being pulled also led to stronger warnings for other NSAIDs: http://www.fda.gov/Drugs/DrugSafety/ucm451800.htm http://www.fda.gov/Drugs/DrugSafety/ucm451800.htm