Well, I keep up on my journal reading, and my sister's a medical doctor from Penn. The first serious proposal for preliminary trim5-alpha based gene therapy was

Well, I keep up on my journal reading, and my sister's a medical doctor from Penn. The first serious proposal for preliminary trim5-alpha based gene therapy was released in 2015, without much reaction. Some previous work has been done. Modified human T-cells with a copy of new world monkey trim5-alpha. The result was successful in vitro. I believe that was 2008. My point was really, "Why doesn't this rather straightforward mechanism receive more time and research?" *Disclaimer: I have worked in bioinformatics.