3 ms·
It doesn't matter if the mutations were there to begin with. Even when the mutation occurs after a change in the environment, it's not the change in the environ
by adrusi 11y ago
It doesn't matter if the mutations were there to begin with. Even when the mutation occurs after a change in the environment, it's not the change in the environment that caused the mutation, mutations are random. What matters is if the treatment made the mutations viable.
- nonbel 11y agoSure it matters. They say that "all mutations cluster around the Cas9 cleavage site at position −3, suggesting that the escape mutations were generated in the process of HIV-1 inhibition." http://www.ncbi.nlm.nih.gov/pubmed/26796669 http://www.ncbi.nlm.nih.gov/pubmed/26796669 Perhaps instead the virus that infected some cells that was already mutated, so it was resistant to the cleavage (due to lacking the recognition site). These are totally different mechanisms.