The way I solve this on my Eee is to actually move the hand when going for the arrow keys instead of twisting it. Bending the fingers is also much less evil tha

The way I solve this on my Eee is to actually move the hand when going for the arrow keys instead of twisting it. Bending the fingers is also much less evil than twisting them. Beyond that, regular joint massage helps, try and find someone around you who knows how to do it, and get them to teach you. The biggest amount of stress on my wrist comes from sports/martial arts rather than computer use, so I need to massage my wrists regularly anyway, but it definitely does help with the issues caused by computer use as well.