Yes, there are many counterexamples, but most compounds that are safe in large acute doses are safe in small long-term doses. Given this evidence, the studies s

Yes, there are many counterexamples, but most compounds that are safe in large acute doses are safe in small long-term doses. Given this evidence, the studies showing neuroprotective effects, and the fact that modafinil has been around since the 80's, I assign high probability to its long-term safety.