That probably depends on the rules in your state. You should contact the agency that handles it. On my unemployment (CA) form it asks me if I earned any money f

That probably depends on the rules in your state. You should contact the agency that handles it. On my unemployment (CA) form it asks me if I earned any money for the weeks I am claiming for. Presumably they subtract any money I earned for those weeks from the benefit amount I would receive, so it could be that if your employee does not earn any commission for a given claim period then they would not lose any unemployment benefit but its always safest to get it from the horses mouth.