> If you're going to deliver enough lentivirus into an HIV patient to edit all the HIV out of their T-cells, you're going to provoke a massive immune response

> If you're going to deliver enough lentivirus into an HIV patient to edit all the HIV out of their T-cells, you're going to provoke a massive immune response From a layman's point of view: isn't that exactly what HIV does in the first place, only faster? As I understand it, on initial infection there can be a major immune response, causing skin rashes or worse.