3 ms·
Apparently this doesn't only diminish the infection, but can supposedly confer resistance? "When evaluating a therapeutic strategy based on CRISPR/Cas9, it is
by zymhan 11y ago
Apparently this doesn't only diminish the infection, but can supposedly confer resistance?
"When evaluating a therapeutic strategy based on CRISPR/Cas9, it is critical to understand that not only will HIV-1 be eliminated from latently infected cells, but the majority of uninfected cells will become resistant to HIV infection. Thus, there is a high likelihood that rebounding viral infections will be contained by the resistant cells."
- L_Rahman 11y agoThis confused me as well. Based on my skimming, the paper doesn't speculate on why this appears to be true, but it's very interesting that the researchers observed this phenomenon at all.
- jameskraus 11y agoHIV is a virus whose genes are rapidly mutating, even in a single individual (due partially to its genome being based on RNA, not DNA). Due to random chance, it's highly likely that an individual will already have a resistant strain of HIV in their body before they underwent this treatment, so after the treatment, only that strain would be left.