So here's the thing - people like to say "This doesn't look like a big enough study..." but you never see them say what would be. Basically: How do you justify

So here's the thing - people like to say "This doesn't look like a big enough study..." but you never see them say what would be. Basically: How do you justify your belief that their sample size is to small? There are calculations to do this. 60 patients is, while small, pretty standard for a study like this, and decently powered. The authors also used the appropriate techniques to deal with small numbers in particular strata when they were controlling for the variables they mention.