3 ms·

Former neuroscientist here. Emotions are not confined to the right frontotemporal area. There's multiple regions involved. It appears the TMS here was targeted

by KingMob 11y ago

Former neuroscientist here. Emotions are not confined to the right frontotemporal area. There's multiple regions involved. It appears the TMS here was targeted on dorsolateral PFC, but keep in mind that there will be spreading effects, and presumably post-treatment effects, too, that can be quite widespread.

neurotech1 11y ago
> Emotions are not confined to the right frontotemporal area. That is true. I should have been more specific. Just out of interest, do you believe that neuronal connectivity between regions of the brain are involved in ASD?
- KingMob 11y ago
  That's one of the more likely theories yeah. While the defining ASD characteristic is impaired social processing, which seems like it would be specific, scans show it has relatively wide effects throughout the brain. There's a host of differences. Some are possibly connectivity-based. Localized processing seems hyperactive, and longer-distance processing is hypoactive. But, there are other issues as well. In developing ASD brains, there have been shown to be areas of excess cortical thickening, areas of cortical thinning, underactivation, etc. Connectivity certainly plays a role, but given that structure and function are so deeply interrelated, it doesn't make much sense to try and separate them. We think there's a strong genetic component, but nobody's been able to figure it out yet. It appears to be more developmental/structural, but there could also be a neurotransmitter component, given that a large fraction of ASD people have elevated serotonin levels, and report intestinal issues (intestines have huge numbers of ST receptors). In short, pretend you're debugging an intermittent parallel error in a network 50x greater than the total number of computers on earth, every computer had to coordinate its protocols on the fly, and your only tools are telnet and email. I respect what my former colleagues do, but reality was way too murky.

by KingMob 11y ago

neurotech1 11y ago

> Emotions are not confined to the right frontotemporal area. That is true. I should have been more specific. Just out of interest, do you believe that neuronal connectivity between regions of the brain are involved in ASD?

KingMob 11y ago
That's one of the more likely theories yeah. While the defining ASD characteristic is impaired social processing, which seems like it would be specific, scans show it has relatively wide effects throughout the brain. There's a host of differences. Some are possibly connectivity-based. Localized processing seems hyperactive, and longer-distance processing is hypoactive. But, there are other issues as well. In developing ASD brains, there have been shown to be areas of excess cortical thickening, areas of cortical thinning, underactivation, etc. Connectivity certainly plays a role, but given that structure and function are so deeply interrelated, it doesn't make much sense to try and separate them. We think there's a strong genetic component, but nobody's been able to figure it out yet. It appears to be more developmental/structural, but there could also be a neurotransmitter component, given that a large fraction of ASD people have elevated serotonin levels, and report intestinal issues (intestines have huge numbers of ST receptors). In short, pretend you're debugging an intermittent parallel error in a network 50x greater than the total number of computers on earth, every computer had to coordinate its protocols on the fly, and your only tools are telnet and email. I respect what my former colleagues do, but reality was way too murky.