You can configure prefix-less keybindings for tmux. It might not be a good idea to do globally unless you know that none of your terminal apps will depend on th

You can configure prefix-less keybindings for tmux. It might not be a good idea to do globally unless you know that none of your terminal apps will depend on the same key, but having that in per-project (or per-language) configs might be ok. I find mouse and clipboard support a bit annoying but there's been changes to that in recent versions of tmux and I haven't reviewed what they do yet. I haven't got to that part quite yet, but I've been considering adding a few global key shortcuts that would route e.g. run/continue/next/step to my debugger window, regardless of which tmux window is active.