I've always dreamed of picking a new city, and then hunting for a job there until I found one. I did this once years ago, and the hardest part was just flying

I've always dreamed of picking a new city, and then hunting for a job there until I found one. I did this once years ago, and the hardest part was just flying out for interviews (from the old city to the new one) -- and then obviously all the logistics of moving. But you only have to do it once. If you know at least one person in your new city, it can really clear a lot of the early confusion. (I once thought about posting a Craigslist ad offering a free dinner to anyone who'd also come and talk to me about the city...) And Meetups are a great way to find people who share your interests, whether it's tech or a certain sport or even just going out to movies....