>Hint: doing big studies just so you can fail to find an effect is nonsensical. Instead, do big studies so you can put a tight upper bound on the effect. Don't

>Hint: doing big studies just so you can fail to find an effect is nonsensical. Instead, do big studies so you can put a tight upper bound on the effect. Don't tell me that vaccines don't have a significant (or discernible) effect on autism. Tell me that, with 99.9% confidence, you have ruled out the possibility that vaccines have caused more than ten autism cases in the entire history of vaccines, and that, most likely, they've caused no cases whatsoever (or whatever the right numbers are). Checking the bounds of a 100(1-a)% confidence interval is exactly equivalent to checking for a p-value below a%.