I think you make a very salient point. From the abstract: > We identified all large NHLBI supported RCTs between 1970 and 2012 evaluating drugs or dietary sup

I think you make a very salient point. From the abstract: > We identified all large NHLBI supported RCTs between 1970 and 2012 evaluating drugs or dietary supplements for the treatment or prevention of cardiovascular disease. So this is for a narrow field where there are effective drugs already and where all the low hangoing fruits are fully picked because the business opportunity is huge.