For me it comes down to what language are you more comfortable using. Plain old JavaScript with Babel ? React TypeScript ? Angular 2 Angular 2 is much more OO

For me it comes down to what language are you more comfortable using. Plain old JavaScript with Babel ? React TypeScript ? Angular 2 Angular 2 is much more OO style GUI lib - if you've ever worked with stuff with WPF you'll recognize the patterns immediately - focus on DI, property bindings and attributes, class based design, etc. It really works well with TS and IDEs React + TS is quirky to say the least - not just the base lib but the ecosystem - for example immutable.js is annoying to use with TS (creating typed records). It can be done but I'm not sure it's worth the effort. But one huge consideration is that React has been "out there" for a while now - there's a ton of quality work available on top of it. In Angular 2 even the basics are in flux like animations and stuff like material design components are nowhere near in sight.