I highly doubt it. I use AdAway for Android, and my current (/system)/etc/hosts file is 58626 lines with no noticeable lag on my Nexus 7 2012 and my Nexus 9. I

I highly doubt it. I use AdAway for Android, and my current (/system)/etc/hosts file is 58626 lines with no noticeable lag on my Nexus 7 2012 and my Nexus 9. I would assume local IO would usually beat network IO.