In terms of fighting with Apache/Nginx/WSGI, I think you'd have similar issues with most other frameworks. During development, you can run a self-hosted Django

In terms of fighting with Apache/Nginx/WSGI, I think you'd have similar issues with most other frameworks. During development, you can run a self-hosted Django instance with `python manage.py runserver`. Once you've developed your application and are ready to deploy, I'd personally suggest this guide (although others may have different opinions): http://uwsgi-docs.readthedocs.org/en/latest/tutorials/Django_and_nginx.html http://uwsgi-docs.readthedocs.org/en/latest/tutorials/Django.... It boils down to installing uwsgi, creating a wsgi config file (which specifies the path to your Django app, and it's name), and then telling nginx to proxy requests to your wsgi socket.