3 ms·

That's brutal. I'm never doing drugs.

• mirimir 11y ago
  That's one option. But for sure, one should be careful with drugs that down-regulate receptors, especially those that do so long-term or permanently. As cocaine does. Receptor down-regulation is the mechanism for biological addiction. Cocaine is less addictive than nicotine, ethanol or opiates. You need considerable high-dose exposure to do serious damage. But once it's done, you're screwed.
  • deleted 11y ago
    [deleted]