From Journal of Immunology with impact factor 4.92 Note the following quotes are take from an article that's "aim is to sound a word of caution" about the use

From Journal of Immunology with impact factor 4.92 Note the following quotes are take from an article that's "aim is to sound a word of caution" about the use of mice as a substitute for human studies. Even they note how well mice have served and will continue to serve as a model for human biology. "Mice are the mainstay of in vivo immunological experimentation and in many respects they mirror human biology remarkably well." "In this review our aim is not to suggest that the mouse is an invalid model system for human biology. Clearly, with so many paradigms that translate well between the species, and with the relative ease with which mice can now be genetically manipulated, mouse models will continue to provide important information for many years to come. " http://www.jimmunol.org/content/172/5/2731.full http://www.jimmunol.org/content/172/5/2731.full