I'm not sure how well that prestige is earned. NEJM has to retract substantially more papers than any other high-profile journal: http://retractionwatch.com/20

I'm not sure how well that prestige is earned. NEJM has to retract substantially more papers than any other high-profile journal: http://retractionwatch.com/2011/08/11/is-it-time-for-a-retraction-index/ http://retractionwatch.com/2011/08/11/is-it-time-for-a-retra... If the papers they publish get more scrutiny, they will undoubtedly have to retract even more.