The biggest opportunity for impact would be to find some politically incorrect / heterodox studies in areas where existing power structures have no incentive to

The biggest opportunity for impact would be to find some politically incorrect / heterodox studies in areas where existing power structures have no incentive to fund. Nutrition comes to mind but it's a pretty crowded field. Alternately I think funding more open source legal docs like the SAFE could offer huge social ROI. (Perhaps in non startup legal areas.)