3 ms·
The simple notion is that you want long telomeres to resist aging. Cancer cells "want" long telomeres to maintain their "cellular immortality", their ability to
by adenadel 11y ago
The simple notion is that you want long telomeres to resist aging. Cancer cells "want" long telomeres to maintain their "cellular immortality", their ability to divide indefinitely. From Wikipedia:
"Telomeres are critical for maintaining genomic integrity and studies show that telomere dysfunction or shortening is commonly acquired during the process of tumor development. Short telomeres can lead to genomic instability, chromosome loss and the formation of non-reciprocal translocations; and telomeres in tumor cells and their precursor lesions are significantly shorter than surrounding normal tissue."[0]
"Cancer cells require a mechanism to maintain their telomeric DNA in order to continue dividing indefinitely (immortalization). A mechanism for telomere elongation or maintenance is one of the key steps in cellular immortalization and can be used as a diagnostic marker in the clinic. Telomerase, the enzyme complex responsible for elongating telomeres through the addition of telomere repeats to the ends of chromosomes, is activated in approximately 80% of tumors."[0]
It's not as simple as long vs short.
0. https://en.wikipedia.org/wiki/Telomere#Cancer https://en.wikipedia.org/wiki/Telomere#Cancer
- nonbel 11y agoInteresting. Wikipedia makes that 80% claim, citing: Aschacher; Wolf; Enzmann; Kienzl (2015). "ALINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines". Oncogene. doi:10.1038/onc.2015.65. Aschacher et al write: "In about 80% of tumour cells, telomere maintenance is controlled by telomerase (TA), a reverse transcriptase, which adds DNA repeats onto chromosomal ends."12, 22, 23, 24, 25 I checked all five references and none had anything about this 80% of tumors number. It appears to be made up.