So, with its grain of salt, the Wikipedia article on MDMA begins the discussion with this statement: > MDMA acts primarily as a presynaptic releasing agent of

So, with its grain of salt, the Wikipedia article on MDMA begins the discussion with this statement: > MDMA acts primarily as a presynaptic releasing agent of serotonin, norepinephrine, and dopamine, which arises from its activity at trace amine-associated receptor 1 (TAAR1) and vesicular monoamine transporter 2 (VMAT2). It goes on to state that MDMA acts as an inhibitor of VMAT2, which correlates to an increase of the neurotransmitters in the space near that receptor's neuron. I think this means that it does operate on the brain by encouraging the release of more serotonin, norepinephrine and dopamine. [1]: https://en.wikipedia.org/wiki/MDMA#Pharmacodynamics https://en.wikipedia.org/wiki/MDMA#Pharmacodynamics