Wait, what? How do you statistically compensate for a sample size of one, or zero? The issue here isn't contaminants in the sample, it's the markers (i.e., wh

Wait, what? How do you statistically compensate for a sample size of one, or zero? The issue here isn't contaminants in the sample, it's the markers (i.e., what is being tested for) in the sample. If marker isn't uniformly distributed, then these small samples might not even find it in them.