6 ms·
This article seems a little inaccurate to me, or at least incomplete. On phobias, it's not quite as simple as a 'fear memory', although certainly a part of it
by spangry 11y ago
This article seems a little inaccurate to me, or at least incomplete.
On phobias, it's not quite as simple as a 'fear memory', although certainly a part of it when we're discussing 'conditioned fear' (e.g. PTSD). There's a part of your brain called the amygdala that is implicated in modulation of memory formation and emotional processing. It's part of the limbic system, which is tied in to the body's autonomic nervous system. This controls your 'fight or flight' response, essentially a sudden release of adrenaline into your system which causes 'anxiety symptoms': increased heart rate, increased perspiration, butterflies in stomach (due to diversion of blood flow to large muscles in your limbs).
The amygdala is sort of like a 'heuristic co-processor' that receives sensory input earlier than other parts of the brain. If the input matches a heuristic, the body's fight or flight response is activated. If the amygdala is dysfunctional, is 'pre-programmed' with heuristics now considered maladaptive, or you've had experiences that have 'programmed' inappropriate heuristics, it will activate your fight or flight response in response to non-threatening stimuli.
Drugs like propranolol, which I take daily for a panic disorder, antagonise (i.e. block) beta-adrendergic receptors, blocking the action of adrenaline and noradrenaline, which dampens the fight or flight response. This reduces or eliminates panic/anxiety like symptoms, and alters how memories are encoded while under its effects (however I'm not clear on whether this interferes with memory formation, or whether it causes the memories to be encoded in a different way).
The part I find most interesting is the 'pre-programmed maladaptive heuristics' still present in our heuristic database. Evolution is a slow process, and has not caught up to our rapidly changing context. For instance, if you've ever given a public speech, you've probably experienced a 'fight-or-flight' response. It's not because you've had some bad past experience with public speaking that has conditioned a 'fear response'; it's because of a left over heuristic in your amygdala that may have been adaptive a thousands of years ago.
Humans used to live in small tribes or groups with maybe a dozen other humans, and the only other humans they might have contact with in their life would be when fighting other groups for resources. If you publicly humiliated yourself in this context, it would have likely meant elimination from the gene pool or possibly even death. In a modern context, where you're giving a speech to a room full of people in another country, this isn't even mildly the case. But evolution is a slow process, so many of us still experience a fight or flight response anyway, which is maladaptive.
- sridca 11y agoIn your experience taking this drug, does propranolol have any effect on 'pre-programmed maladaptive heuristics'?
- spangry 11y agoI'm not 100% sure. I think so, possibly in the same way that exposure therapy can be helpful. On rare occasions when I've forgotten to take my propranolol dose, I think I experienced less severe panic reactions to provoking stimuli compared to in the past. This might be due to higher levels of 'exposure' when taking propranolol without a concurrent onset of panic symptoms, leading to a partial reversal of 'fear conditioning' (perhaps better characterised as 're-conditioning'?) In my case I've found it to be very effective at treating the symptoms of my panic disorder, which are mostly physical/autonomic nervous system mediated. I think beta-blockers wouldn't be as effective for anxiety disorders where the symptoms are mostly 'mental' (e.g. catastrophic thinking, irrational anxious beliefs etc.). tl;dr - Propranolol is great for 'physical' anxiety, possibly not as effective for 'mental' anxiety
- taurath 11y agoWonderful description - thank you very much. Sounds very promising as a treatment for post-CBT resistant anxiety, which is a simple word for what I have. I can feel a physical fear response coming on and a large drain in my willpower resources based on very small stimuli that aren't cognatively fear-inducing. Sounds like this could help calm my overactive fight or flight system - its been on my list to try for a long while.