I have the 5DsR, which is the same as the 5Ds but with an anti-aliasing cancellation filter. I can confirm that at the pixel density on this camera, it is VERY

I have the 5DsR, which is the same as the 5Ds but with an anti-aliasing cancellation filter. I can confirm that at the pixel density on this camera, it is VERY challenging to get perfectly sharp photos if your shutter speeds drop too low. Pixel-level blur is a real problem on these cameras. Conversely, on medium format, you have a little bit more leeway for tripod shake as the individual pixels are larger. I have no experience with analog photography, So I'm not sure whether these same considerations are present.