Touch screens obviously aren't the answer here, but a good trackpad setup might be okay. I used to use Apple's "magic trackpad" when I had a macintosh desktop,

Touch screens obviously aren't the answer here, but a good trackpad setup might be okay. I used to use Apple's "magic trackpad" when I had a macintosh desktop, and it did gesture inputs really well, though I always seemed to run into discomfort/strain issues earlier than I did with a mouse (which is part of why I switched back.) That could be unique to me, but I'd guess that the need to hover your hand above the pad is not good for anyone. I'd be up for trying that setup again if someone had a good idea to solve that problem.