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* Dangerous combinations, like alcohol, can be a contributing factor. * Black market drugs can have widely varying contents and potencies (rat poison and fenta
by fineIllregister 11y ago
* Dangerous combinations, like alcohol, can be a contributing factor.
* Black market drugs can have widely varying contents and potencies (rat poison and fentanyl).
* Tolerance changes have already been mentioned.
* Taking drugs in a consistent place and/or circumstances causes the body to prepare for consumption (like Pavlov's dogs salivating at the bell). Unfamiliar situations can catch the body off guard.