3 ms·

Yeah, bold claims.

by e40 11y ago

Yeah, bold claims.

paulmd 11y ago
That article smells fishy as hell. And if Alzheimer's were treatable, today, it would be a huge huge deal, not something being peddled around as a miracle cure on the basis of a 10-person "study". They're making progress though. They've found at least one candidate drug that appears to clear up the Amyloid-beta plaques in mice. http://www.nature.com/ncomms/2015/151208/ncomms9997/full/ncomms9997.html http://www.nature.com/ncomms/2015/151208/ncomms9997/full/nco...
- DrScump 11y ago
  But are Amyloid-beta plaques a proven cause of Alzheimer's? Or is it just correlation at this point?
  - paulmd 11y ago
    If you inject amyloid-beta peptide extract from an AD-infected mouse into the brain of another, it then starts growing the usual plaques[1]. And A-beta plaque deposits are basically the distinguishing characteristic of Alzheimer's. So in my book that's very strong experimental evidence that A-beta is the causal mechanism of Alzheimer's and not merely a side effect. It seems to be basically a misfolded protein, like CJD or mad-cow. Usual caveats - nothing in science is ever proven to 100% certainty. Remove seal before use. Ask your doctor if Alzheimer's is right for you. [1] http://www.jneurosci.org/content/20/10/3606.full http://www.jneurosci.org/content/20/10/3606.full
- harveywi 11y ago
  There could be some fishiness to it. However... One of the things I noticed right away is that the therapeutic programs prescribed to the patients patients in the study combined autophagy/ketosis (fasting 12 hours at night), low-glycemic diets, daily exercise, stress reduction, and sleep optimization. A recent paper [1] concluded that "[...] the term 'type 3 diabetes' accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM." Something to think about. [1] De la Monte SM, Wands JR. Alzheimer’s Disease Is Type 3 Diabetes–Evidence Reviewed. Journal of diabetes science and technology (Online). 2008;2(6):1101-1113. Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/

Yeah, bold claims.

by e40 11y ago

Yeah, bold claims.

That article smells fishy as hell. And if Alzheimer's were treatable, today, it would be a huge huge deal, not something being peddled around as a miracle cure on the basis of a 10-person "study". They're making progress though. They've found at least one candidate drug that appears to clear up the Amyloid-beta plaques in mice. http://www.nature.com/ncomms/2015/151208/ncomms9997/full/ncomms9997.html http://www.nature.com/ncomms/2015/151208/ncomms9997/full/nco...

DrScump 11y ago
But are Amyloid-beta plaques a proven cause of Alzheimer's? Or is it just correlation at this point?
- paulmd 11y ago
  If you inject amyloid-beta peptide extract from an AD-infected mouse into the brain of another, it then starts growing the usual plaques[1]. And A-beta plaque deposits are basically the distinguishing characteristic of Alzheimer's. So in my book that's very strong experimental evidence that A-beta is the causal mechanism of Alzheimer's and not merely a side effect. It seems to be basically a misfolded protein, like CJD or mad-cow. Usual caveats - nothing in science is ever proven to 100% certainty. Remove seal before use. Ask your doctor if Alzheimer's is right for you. [1] http://www.jneurosci.org/content/20/10/3606.full http://www.jneurosci.org/content/20/10/3606.full
harveywi 11y ago
There could be some fishiness to it. However... One of the things I noticed right away is that the therapeutic programs prescribed to the patients patients in the study combined autophagy/ketosis (fasting 12 hours at night), low-glycemic diets, daily exercise, stress reduction, and sleep optimization. A recent paper [1] concluded that "[...] the term 'type 3 diabetes' accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM." Something to think about. [1] De la Monte SM, Wands JR. Alzheimer’s Disease Is Type 3 Diabetes–Evidence Reviewed. Journal of diabetes science and technology (Online). 2008;2(6):1101-1113. Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/