There would be better ways to spend your time than TAOCP. If you want to scratch that itch, a better way would be Cormen, Leiserson, Rivest, and Stein's Intro

There would be better ways to spend your time than TAOCP. If you want to scratch that itch, a better way would be Cormen, Leiserson, Rivest, and Stein's Intro to Algorithms (https://mitpress.mit.edu/books/introduction-algorithms https://mitpress.mit.edu/books/introduction-algorithms). I'm not aware of such a universal reference for the interaction between algorithms and architecture ("...pipeline stalls, cache performance, ..."). Until that day comes...TAOCP sure looks nice on the bookshelf.