Depends on the screenreader. And unfortunately, also depends on the screenreader + browser. If the proper HTML tags are used, and role attributes are applied,

Depends on the screenreader. And unfortunately, also depends on the screenreader + browser. If the proper HTML tags are used, and role attributes are applied, it should work fairly well. The concern, however, is the weight of the page. But don't let React fool you - they try to do the same thing - rendering HTML with JSX. And the same problems can present themselves there.