I did some customer development on these treatment issues. One interesting anecdote was from a gentleman whose family was predisposed to a given disease which

I did some customer development on these treatment issues. One interesting anecdote was from a gentleman whose family was predisposed to a given disease which had a treatment pathway consisting of drugs A, then B, then C. Patients were not allowed to progress to B unless A had failed and were not allowed to progress to C unless C had failed. Prior family members had been treated on this treatment pathway and had found that only drug C 'worked properly' (define that how you will). Therefore this group created their own protocol they shared amongst the family for how to act and what to say to doctors to rapidly progress from drug A to B and finally to C.