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Is there reason to think that bacteria with every gene for antibiotic resistance would be at all viable? It seems likely that these genes have other negative ef

Is there reason to think that bacteria with every gene for antibiotic resistance would be at all viable? It seems likely that these genes have other negative effects on fitness that make them unlikely to spread significantly in the absence of the antibiotic.

dredmorbius 11y ago
The tendency, under selective pressures, is for organisms to become more fit over time. By applying constant antibiotic-induced generalised selective pressure, you're greatly increasing those odds
- TTPrograms 11y ago
  "More fit" only makes sense with regards to the pressure. I.e. the bacteria may survive antibiotics, but that may come at the expense of general pathogenicity. The fact that the gene is not already widespread suggests that in the absence of the selective pressure of the antibiotic it has other effects that decrease fitness in a typical environment.
  - aftabh 11y ago
    I agree with your statement if it was a single (or a limited number of) species of antibiotic resistance bacteria. But, the problem seems to be that they'll be acting more like a gang (where each gang member is a species of bacteria) by multiplying and transferring their weapons (in this case, antibiotic resistant MCR-1 gene) among different bacteria species by means of horizontal gene transfer[1]. Here, horizontal gene transfer means bacteria don't need to carry the "general pathogenicity" as parts of its genome and transfer to future generations (by sexual/asexual re-production)[2]. They only have to be good (and will be damn good by MCR-1 gene) at whatever pathogen they carry. "Horizontal gene transfer" will take care of the rest. I think we'll get a better idea of the problem I'm trying to explain if we look at it from "Unix philosophy" perspective which "favors composability as opposed to monolithic design"[3]. I hope that I'm decidedly proven wrong in this regard. But, it's just a hope. Note: I don't have any formal education/background in medical sciences. --- [1] http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00424-7/abstract http://www.thelancet.com/journals/laninf/article/PIIS1473-30... [2] https://en.wikipedia.org/wiki/Horizontal_gene_transfer https://en.wikipedia.org/wiki/Horizontal_gene_transfer [3] https://en.wikipedia.org/wiki/Unix_philosophy https://en.wikipedia.org/wiki/Unix_philosophy

dredmorbius 11y ago

The tendency, under selective pressures, is for organisms to become more fit over time. By applying constant antibiotic-induced generalised selective pressure, you're greatly increasing those odds

TTPrograms 11y ago
"More fit" only makes sense with regards to the pressure. I.e. the bacteria may survive antibiotics, but that may come at the expense of general pathogenicity. The fact that the gene is not already widespread suggests that in the absence of the selective pressure of the antibiotic it has other effects that decrease fitness in a typical environment.
- aftabh 11y ago
  I agree with your statement if it was a single (or a limited number of) species of antibiotic resistance bacteria. But, the problem seems to be that they'll be acting more like a gang (where each gang member is a species of bacteria) by multiplying and transferring their weapons (in this case, antibiotic resistant MCR-1 gene) among different bacteria species by means of horizontal gene transfer[1]. Here, horizontal gene transfer means bacteria don't need to carry the "general pathogenicity" as parts of its genome and transfer to future generations (by sexual/asexual re-production)[2]. They only have to be good (and will be damn good by MCR-1 gene) at whatever pathogen they carry. "Horizontal gene transfer" will take care of the rest. I think we'll get a better idea of the problem I'm trying to explain if we look at it from "Unix philosophy" perspective which "favors composability as opposed to monolithic design"[3]. I hope that I'm decidedly proven wrong in this regard. But, it's just a hope. Note: I don't have any formal education/background in medical sciences. --- [1] http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00424-7/abstract http://www.thelancet.com/journals/laninf/article/PIIS1473-30... [2] https://en.wikipedia.org/wiki/Horizontal_gene_transfer https://en.wikipedia.org/wiki/Horizontal_gene_transfer [3] https://en.wikipedia.org/wiki/Unix_philosophy https://en.wikipedia.org/wiki/Unix_philosophy