4 ms·

The title is "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques" and it does not say th

The title is "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques" and it does not say that it reduces memory, it says "EPPS reduces Aβ-aggregate-induced memory deficits in mice" but they also say that "We observed substantial rescue of working memory deficits in Aβ-infused mice by EPPS treatment". Of course this is only small part of the paper and I have no training to appreciate it more.

Brakenshire 11y ago
I'm not an expert either, but as far I can see: The diagramme showing how much memory is recovered is figure one. White is before the administration of the "Alzheimer's protein" (AB protein), black is without the new clearing chemical, blue is with it, and then the different blue columns showing different concentrations. Fig 1c is prophylactic treatment (clearing molecule administered before, during and after the AB protein), Fig 1d is clearing molecule administered alongside AB protein. The impairment seems to more or less recover fully back up to where it was originally, in all four combinations of timing and clearing molecule concentration. But bear in mind: * The mouse model for Alzheimer's seems to be very, very simplified - as far as I can see they literally inject big doses of these proteins directly into the brain in order to induce Alzheimer's like symptoms, that doesn't mean this is equivalent at all to the complex chemical processes underlying Alzheimer's. AB proteins are observed in Alzheimer's patients, but they are also observed in healthy patients, and other proteins are also seen in Alzheimer's patients, some of which are recently thought more likely to be the underlying driver of the disease. * All of this occurs over a very short period of time. Someone who has developed symptoms of Alzheimer's will have had the disease process occurring for many years beforehand. Recovery a few days after administration of the protein doesn't mean that damage would be recoverable years later. Edit: I'm actually just looking at the first experiment, they also do longer term trials with a mouse model which has been genetically altered to over-expresses the AB protein. Arguably this is still a very over-simplified model, but it does more to address the time question. They say Alzheimer's symptoms usually develop at 5 months, then they administer the clearing molecule at 10.5 months for 3 months. Those experiments shows about half the deficit being recovered relative to normal age-matched mice.
geoelectric 11y ago
Yeah, good highlight. My skim seems to indicate it means working memory too. That's a different concept than the kind of memory lapses most people associate with Alzheimer's--more about holding information in your head long enough to process in a subsequent step or file in long-term storage. It's one of the major deficits in ADHD, to the extent that clarifies what the effects might be.

Brakenshire 11y ago

I'm not an expert either, but as far I can see: The diagramme showing how much memory is recovered is figure one. White is before the administration of the "Alzheimer's protein" (AB protein), black is without the new clearing chemical, blue is with it, and then the different blue columns showing different concentrations. Fig 1c is prophylactic treatment (clearing molecule administered before, during and after the AB protein), Fig 1d is clearing molecule administered alongside AB protein. The impairment seems to more or less recover fully back up to where it was originally, in all four combinations of timing and clearing molecule concentration. But bear in mind: * The mouse model for Alzheimer's seems to be very, very simplified - as far as I can see they literally inject big doses of these proteins directly into the brain in order to induce Alzheimer's like symptoms, that doesn't mean this is equivalent at all to the complex chemical processes underlying Alzheimer's. AB proteins are observed in Alzheimer's patients, but they are also observed in healthy patients, and other proteins are also seen in Alzheimer's patients, some of which are recently thought more likely to be the underlying driver of the disease. * All of this occurs over a very short period of time. Someone who has developed symptoms of Alzheimer's will have had the disease process occurring for many years beforehand. Recovery a few days after administration of the protein doesn't mean that damage would be recoverable years later. Edit: I'm actually just looking at the first experiment, they also do longer term trials with a mouse model which has been genetically altered to over-expresses the AB protein. Arguably this is still a very over-simplified model, but it does more to address the time question. They say Alzheimer's symptoms usually develop at 5 months, then they administer the clearing molecule at 10.5 months for 3 months. Those experiments shows about half the deficit being recovered relative to normal age-matched mice.

geoelectric 11y ago

Yeah, good highlight. My skim seems to indicate it means working memory too. That's a different concept than the kind of memory lapses most people associate with Alzheimer's--more about holding information in your head long enough to process in a subsequent step or file in long-term storage. It's one of the major deficits in ADHD, to the extent that clarifies what the effects might be.