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I want to comment on the version of your comment that you edited. You stated that you believe a blood glucose of 140 mg/dl would cause diabetic neuropathy wher

I want to comment on the version of your comment that you edited. You stated that you believe a blood glucose of 140 mg/dl would cause diabetic neuropathy whereas your GP quoted a blood glucose of 150 mg/dl as causative of diabetic neuropathy. It doesn't seem like things are as starkly different as that. Patients usually develop diabetic neuropathy over many years, so it's not clear that your GP would have 'guaranteed you diabetic neuropathy'.

kefka 11y ago
Weird. I've edited no posts at least in the last week or so.(this post edited to add lines to show separation between studies.) And yes, I cite 140mg/dL causes neural damage and shows itself as diabetic neuropathy. Proof. _____________________________________ >Diabetic Retinopathy Develops at "Prediabetic" Blood Sugar Levels NIH News: Diabetic Retinopathy Occurs in Pre-Diabetes. http://www.nih.gov/news/pr/jun2005/niddk-12.htm http://www.nih.gov/news/pr/jun2005/niddk-12.htm Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies Wong TY, et al Lancet 2008; 371: 736-743. Association of A1C and Fasting Plasma Glucose Levels With Diabetic Retinopathy Prevalence in the U.S. Population: Implications for diabetes diagnostic thresholds Yiling J. Cheng et al. Diabetes Care November 2009 vol. 32 no. 11 2027-2032. doi: 10.2337/dc09-0440 Glycemic Thresholds for Diabetes-Specific Retinopathy: Implications for Diagnostic Criteria for Diabetes:The DETECT-2 Collaboration Writing group. Stephen Colagiuri et al. Diabetes Care Published online before print October 26, 2010, doi: 10.2337/dc10-1206 Hemoglobin A1c and Fasting Plasma Glucose Levels as Predictors of Retinopathy at 10 Years: The French DESIR Study. Massin P. et al. Arch Ophthalmol.2011 Feb;129(2):188-195. _____________________________________ > Beta Cell Destruction Begins at 2-hr OGTT Test Readings Over 100 mg/dl (5.6 mmol/L Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Gastaldelli A; Ferrannini E; Miyazaki Y; Matsuda M; De Fronzo RA;Diabetologia 2004 Jan;47(1):31-9) _____________________________________ >Beta Cells Die Off in People Whose Fasting Blood Sugar is Over 110 mg/dl (6.1 mmol/L) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC.Diabetes. 2003;52:102-110. _____________________________________ >Blood Sugars Over 150 mg/dl (8.3 mmol/L) Kill Transplanted Beta Cells in Mice ß-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia. Montserrat Biarnés, Marta Montolio, Victor Nacher, Mercè Raurell, Joan Soler, and Eduard Montanya. Diabetes 51:66-72, 2002 _____________________________________ >Prolonged Exposure to Blood Sugars Over 140 mg/dl (7.8 mmol/L) Kills Human Beta Cells Determinants of glucose toxicity and its reversibility in pancreatic islet Beta-cell line, HIT-T15.Catherine E. Gleason, Michael Gonzalez, Jamie S. Harmon, and R. Paul Robertson.Am J Physiol Endocrinol Metab 279: E997-E1002, 2000. _____________________________________ >One Hour OGTT Result over 155 mg/dl(8.6 mmol/L) Correlates with Markers for Cardiovascular Disease Inflammation markers and metabolic characteristics of subjects with one-hour plasma glucose levels. Gianluca Bardini et al. Diabetes Care Published online before print November 16, 2009, doi: 10.2337/dc09-134 Edited: added lines for clarity between studies.
- QSIITurbo 11y ago
  Your quotes are about destruction of beta cells (not neural damage). The 140 vs. 150 is a moot point: if you're diabetic, you're supposed to get your blood glucose fixed a lot lower than that. Added: I read one of the studies, and it doesn't really controvert your doctors quote. It gives fasting glucose target a lot lower than 140 or 150 (as it should be), and 2hr glucose a lot higher than 150. In essence, I think you're just interpreting these studies as you will without a proper medical training. My advice is: don't start experimenting with your life based on such weak foundation.

kefka 11y ago

Weird. I've edited no posts at least in the last week or so.(this post edited to add lines to show separation between studies.) And yes, I cite 140mg/dL causes neural damage and shows itself as diabetic neuropathy. Proof. _____________________________________ >Diabetic Retinopathy Develops at "Prediabetic" Blood Sugar Levels NIH News: Diabetic Retinopathy Occurs in Pre-Diabetes. http://www.nih.gov/news/pr/jun2005/niddk-12.htm http://www.nih.gov/news/pr/jun2005/niddk-12.htm Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies Wong TY, et al Lancet 2008; 371: 736-743. Association of A1C and Fasting Plasma Glucose Levels With Diabetic Retinopathy Prevalence in the U.S. Population: Implications for diabetes diagnostic thresholds Yiling J. Cheng et al. Diabetes Care November 2009 vol. 32 no. 11 2027-2032. doi: 10.2337/dc09-0440 Glycemic Thresholds for Diabetes-Specific Retinopathy: Implications for Diagnostic Criteria for Diabetes:The DETECT-2 Collaboration Writing group. Stephen Colagiuri et al. Diabetes Care Published online before print October 26, 2010, doi: 10.2337/dc10-1206 Hemoglobin A1c and Fasting Plasma Glucose Levels as Predictors of Retinopathy at 10 Years: The French DESIR Study. Massin P. et al. Arch Ophthalmol.2011 Feb;129(2):188-195. _____________________________________ > Beta Cell Destruction Begins at 2-hr OGTT Test Readings Over 100 mg/dl (5.6 mmol/L Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Gastaldelli A; Ferrannini E; Miyazaki Y; Matsuda M; De Fronzo RA;Diabetologia 2004 Jan;47(1):31-9) _____________________________________ >Beta Cells Die Off in People Whose Fasting Blood Sugar is Over 110 mg/dl (6.1 mmol/L) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC.Diabetes. 2003;52:102-110. _____________________________________ >Blood Sugars Over 150 mg/dl (8.3 mmol/L) Kill Transplanted Beta Cells in Mice ß-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia. Montserrat Biarnés, Marta Montolio, Victor Nacher, Mercè Raurell, Joan Soler, and Eduard Montanya. Diabetes 51:66-72, 2002 _____________________________________ >Prolonged Exposure to Blood Sugars Over 140 mg/dl (7.8 mmol/L) Kills Human Beta Cells Determinants of glucose toxicity and its reversibility in pancreatic islet Beta-cell line, HIT-T15.Catherine E. Gleason, Michael Gonzalez, Jamie S. Harmon, and R. Paul Robertson.Am J Physiol Endocrinol Metab 279: E997-E1002, 2000. _____________________________________ >One Hour OGTT Result over 155 mg/dl(8.6 mmol/L) Correlates with Markers for Cardiovascular Disease Inflammation markers and metabolic characteristics of subjects with one-hour plasma glucose levels. Gianluca Bardini et al. Diabetes Care Published online before print November 16, 2009, doi: 10.2337/dc09-134 Edited: added lines for clarity between studies.

QSIITurbo 11y ago
Your quotes are about destruction of beta cells (not neural damage). The 140 vs. 150 is a moot point: if you're diabetic, you're supposed to get your blood glucose fixed a lot lower than that. Added: I read one of the studies, and it doesn't really controvert your doctors quote. It gives fasting glucose target a lot lower than 140 or 150 (as it should be), and 2hr glucose a lot higher than 150. In essence, I think you're just interpreting these studies as you will without a proper medical training. My advice is: don't start experimenting with your life based on such weak foundation.